In this ground-breaking tour of the human mind, a world-renowned psychiatrist and neuroscientist explores the origins of human emotion through the stories of his patients. Why do we feel what we feel? How do we define ‘sanity’? Can a lost mind be found again? Since the dawn of humankind, mental illness has been one of our greatest causes of suffering as a species. But for the majority of our history, its causes have remained a mystery. Now, science has reached a tipping point. In ‘Connections’, Professor Karl Deisseroth shares his breakthrough discovery, Optogenetics, a biological technique that allows us to decipher the brain’s inner workings using light.

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‘Beautiful to read and packed with cutting-edge science’ Observer

‘Poetic, mind-stretching and, through it all, deeply human’ Daniel Levitin

Mental illness is one of the greatest causes of human suffering, its nature and origin a long-held mystery. But thanks to new science and technology, our understanding has reached a tipping point. In Connections, Professor Karl Deisseroth intertwines his own breakthrough discoveries with moving case studies from his experience as an emergency psychiatry physician, in order to tell a wider story about the origins of human emotion.

Addressing some of the most timeless questions about the human condition while illuminating the roots of misunderstood disorders such as depression, psychosis, schizophrenia and sociopathy, Connections transforms the way we understand the brain, and forges a bold new path forward in our understanding of mental health.

‘Revelatory . . . it recalls the case histories of Oliver Sacks, at times the sweep of Yuval Harari’s Sapiens. He writes with an evident love of words – but also, with a lucid line of scientific enquiry’ Guardian

‘A master storyteller. His graceful prose weaves a tapestry of complex ideas into memorable stories, each illuminated by cutting-edge science. A delight’ Kathryn Mannix, author of With the End in Mind

Additional information

Weight 0.181 kg
Dimensions 19.8 × 12.9 × 1.6 cm










152.4 (edition:23)


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